AlphaFold & CASP: What We Learned
Before constructing the CAH equivalent, we must understand the exact architecture CASP used to turn a 50-year-old unsolved problem into a structured, measurable competition — and how AlphaFold exploited that structure to achieve a discontinuous leap in performance.
CASP Core Mechanism
Target selection, blind prediction, independent scoring, difficulty stratification, and published results are the benchmark primitives CAHSP replicates.
The CAH ↔ CASP Analogy
| Dimension | CASP (Protein Folding) | CAHSP (CAH Sustainability) |
|---|---|---|
| The Problem | Predict 3D protein structure from amino acid sequence | Predict and achieve CAH viability + quality from operational inputs |
| Ground Truth | Experimental structure | CMS HCRIS + MBQIP + claims |
| Primary Metric | GDT_TS | CAHSP-Score composite index (0-100) |
The 5 Problem Classes CAHSP Must Solve
CAHSP as the CAH Equivalent of GDT_TS
90-100Elite
85-89Solved
70-84High
Type A vs. Type B Targets
Type A corresponds to template-available interventions. Type B is free-modeling equivalent with no prior-art template.
Formal Framework
CAHSP(i, t) = 100 * sum_j [w_j * phi_j(Delta s_j(i,t))]
Weights: FI 0.30, QI 0.30, OI 0.20, WI 0.10, CI 0.10
Dual mandate constraint: FI and QI floors required
Implementation Phases
P0
Now
Baseline scoring and target classification
Build HCRIS baseline and classify Type A/B facilities.
P1
Q3 2026
Type A benchmark cycle
Run and score known-template interventions.
P2
Q1 2027
Type B benchmark cycle
Evaluate novel architectures under prospective scoring.
Integrity Rules and Validation Standard
Benchmark Declaration
The CAH problem is solved when a computational solution achieves CAHSP ≥ 85 on Type B targets using MV-CAHI constraints and holds performance for 24 months against HCRIS-grounded validation.
CAHSP in One Frame
5
Problem Classes
85
Breakthrough Score
1,355+
Target CAHs
24mo
Validation Window